In The Big C, Laura Linney portrays Cathy Jamison, a high school teacher who receives a terminal cancer diagnosis. The series explores Cathy's journey as she decides to live life to the fullest and make the most of her remaining time. With a mix of humor and heartbreak, The Big C delves into the complexities of living with a terminal illness and the impact it has on Cathy's relationships with her family and friends. Laura Linney's powerful performance brings depth and authenticity to the character, making The Big C a poignant and thought-provoking series.