To ensure a smooth work trip to Otay Mesa, it is essential to plan for transportation. If you are flying into the area, you can book a flight to San Diego International Airport, which is the closest major airport. From there, you can rent a car or hire a taxi to reach Otay Mesa. Alternatively, if you are traveling from within California, you can consider taking a train or bus to the area. It is also advisable to have a transportation plan for getting around Otay Mesa, such as renting a car or using rideshare services.