In the series The Big C, Laura Linney portrays the lead character, Cathy Jamison, a high school teacher who receives a terminal cancer diagnosis. The show explores Cathy's journey as she navigates her diagnosis and the impact it has on her relationships and outlook on life. Laura Linney's portrayal of Cathy is both heart-wrenching and inspiring, capturing the emotional rollercoaster that comes with facing mortality. The Big C is a poignant and thought-provoking series that tackles difficult topics with sensitivity and humor, and Laura Linney's performance is a standout in the show.