Against Nature, also known as Against the Grain, is a novel by Joris-Karl Huysmans that is considered a seminal work of Decadent literature. It follows the life of Jean des Esseintes, an eccentric aristocrat who retreats from society to indulge in his extravagant and perverse desires. The book explores themes of aestheticism, artificiality, and the rejection of societal norms, capturing the essence of the Decadent movement.