Against Nature, also known as Against the Grain, is a novel by Joris-Karl Huysmans, published in 1884. It follows the life of Jean des Esseintes, an eccentric aristocrat who retreats from society to indulge in his own decadent and artificial lifestyle. The book explores themes of aestheticism, individualism, and the rejection of societal norms, making it a significant work in the Decadence & the Fin-de-Siècle genre.