On the second day, head to Colmar, a beautiful town known for its well-preserved medieval old town. Take a stroll through the cobblestone streets and admire the colorful half-timbered houses. Visit the Unterlinden Museum, which houses an impressive collection of artwork, including the famous Isenheim Altarpiece. In the afternoon, drive to Riquewihr, a charming village surrounded by vineyards. Explore the narrow streets lined with historic buildings and enjoy wine tasting at one of the local wineries.